The product, through brand new York biotech firm RenovaCare, can be rooted in cutting-edge stem cell research. The CellMist System harvests a patient’s stem cells through a little area of unwounded skin (usually one square inch) as well as suspends them in a water-based solution. The SkinGun sprays the solution onto the wound, where brand new skin begins to grow at the cellular level.
“We don’t modify the cells,” said Thomas Bold, an engineer as well as president as well as CEO of RenovaCare. “We don’t do anything with the cells. We just isolate them through the surrounding tissue, put them in a syringe within a water-based solution, as well as we spray them.
“What we’re doing can be all natural,” he added.
The survival of cells shooting out of the SkinGun can be instrumental, since cells “injured” inside process of spraying might not grow properly. According to Bold, 97% of the cells inside syringe remain viable, as well as so the chances of healing the wound are great.
Feasible although experimental
“We’ve seen already a couple dozen patients, as well as we’re very happy about the results,” Bold said.
“Our work in Pittsburgh on the pre-product procedure truly shows only not bad results, with today 47 patient treatments at UPMC Mercy Hospital Burn as well as Trauma Units,” said Dr. Jörg Gerlach, lead author of the case report as well as a professor inside department of surgery at the University of Pittsburgh. He added which he as well as his colleagues are “only today entering the phase of planning clinical studies with RenovaCare.”
Gerlach receives royalties through RenovaCare for his work.
Dr. Robert Glatter, an emergency physician at Lenox Hill Hospital in brand new York, believes CellMist as well as SkinGun are promising, based on his knowledge of existing studies as well as one ongoing human trial in Argentina using stem cells to heal wounds.
“Human studies have shown which which can be feasible, although which’s certainly experimental at which point,” said Glatter, who can be not affiliated with RenovaCare. He added which the SkinGun technology can be an improvement on current stem cell research, though the results “need to be borne out in further studies” before which can be embraced by the burn center community.
Though a lot of stem cell research for use in healing burns can be happening today, “unfortunately, there are very few big randomized controlled studies to date,” noted Dr. Tom Rohrer, a dermatologic surgeon as well as board member of national organizations including the American Society for Dermatologic Surgery as well as the American Society for Laser Medicine as well as Surgery.
“Researchers have used stem cells through bone marrow, fat as well as skin cells,” said Rohrer, who can be not affiliated with RenovaCare. “which appears as if the stem cells through bone marrow as well as fat work better than those through the skin, although which can be a bit too early to tell.”
“Gaining FDA approval can be what we are working on right today,” Bold said.
Recently, another innovative product has transformed which often-necessary aftercare for burn patients.
Help after healing
Not only are patients bothered psychologically, sometimes, their “scars are painful, they’re itchy, they’re thick, as well as they cause loss of function,” said Rokhsar, who can be not affiliated with RenovaCare. Function loss can be a result of “contracture,” in which the scar tissue constricts as well as lessens mobility. After they heal, some burn victims cannot use their limbs.
“One of the breakthroughs inside past couple of years can be the use of fractionated CO2 lasers to Discharge the tension on those type of scars, where people can actually get function back,” Rokhsar said. He explained which these lasers have been in use for various purposes about 10 years.
“The laser evaporates tiny microscopic zones of tissue, almost like which drills tiny holes inside skin in a microscopic fashion, as well as which allows the scar to remodel itself,” Rokhsar said. He added which the efficacy has been established in studies involving veterans who were burned in explosions. Today, many dermatologists use these lasers on burn victims “post facto”: once they’ve healed.
“We’ve been using which. which’s pretty amazing,” Rokhsar said, adding which the lasers Discharge the tension as well as patients get function back “almost immediately.”
Rohrer also finds the results of these lasers “dramatic” although says they’re only the tip of the iceberg when which comes to brand new laser treatments.
“We are also looking at putting stem cells down these vaporized holes to further improve the texture of the skin,” he said. “We also use pulsed dye lasers to improve the red shade of scars. These devices also help normalized skin texture a bit as well. In addition, we are injecting scars with steroids as well as, more importantly, today antimetabolite drugs originally used to treat cancer to improve scar texture.”
An estimated 486,000 burn injuries require medical treatment each year, as well as nearly 40,000 lead to hospitalization, according to the American Burn Association.
Success rates are high when treating burns: through 2005 through 2014, the association calculates a nearly 97% survival rate for patients admitted to burn centers, which average over 0 annual admissions.
Severe burns — second- or third-degree — require excision, explained Glatter.
A first-degree burn harms only the epidermis or the outermost layer of skin; a second-degree burn penetrates the dermis, the middle layer; as well as a third-degree burn affects epidermis, dermis as well as the innermost layer, the subcutis.
Though which can be the standard approach, which can be not without difficulties. The surgical procedure to remove healthy skin can be painful as well as leaves the patient with another wound which must heal, Glatter noted.
“Infection can be often a problem, as well as grafting rates are often poor,” he said. “A not bad percentage of grafts won’t take.” Usually, skin grafts which do take are not cosmetically appealing, with different skin colors.
brand new techniques using stem cells address these issues, he said. Stem cells functionally work better: “If you burn your shoulder as well as you used a stem cell technique, which might look the same as the skin on your shoulder. which might not appear different.”