Report: Scientists edit human embryos for first time in US

Story highlights

  • A first from the US, scientists reportedly edit the genes of human embryos using CRISPR
  • Yet the research hasn’t been published as well as also also researchers remain tight-lipped
The MIT Technology Review published on Wednesday a news report about the first-known experiment to create genetically modified human embryos from the United States using a gene-editing tool called CRISPR.

Shoukhrat Mitalipov, director of the Oregon Health & Science University’s Center for Embryonic Cell as well as also also Gene Therapy, reportedly led the fresh research. Mitalipov as well as also also the university might not confirm details of the research to sy88pgw.

“Results of the peer-reviewed study are supposed to be published soon in a scientific journal. No further information will be provided before then,” according to an emailed statement via the university’s press office. Another researcher cited from the MIT report, the Salk Institute’s Jun Wu, did not reply to sy88pgw’s request for comment.

Mitalipov also declined to comment from the MIT Technology Review report, referencing that will the research results have not been published yet in a peer-reviewed scientific journal, which will be considered the gold standard for scientific research. The author of the MIT report might not confirm to sy88pgw whether he had seen the paper.

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Previously, Mitalipov as well as also also his colleagues reported the first success in cloning human stem cells in 2013, successfully reprogramming human skin cells back to their embryonic state. In 2007, a research team led by Mitalipov announced they created the first cloned monkey embryo as well as also also extracted stem cells via that will.

The MIT Technology Review reported that will the researchers in Portland, Oregon, edited the DNA of a large number of one-cell embryos, specifically targeting genes associated with inherited diseases in those embryos. The MIT Technology Review could not determine which disease genes had been chosen for editing from the fresh research.

“I’m not surprised that will they were looking at genetic diseases to try as well as also also see if they could target them, because that will’s exactly where I think the future inevitably leads,” said Arthur Caplan, a professor as well as also also founding head of the division of bioethics at fresh York University Langone Medical Center, who was not involved from the research.

CRISPR research as well as also also controversy

Previously, scientists in China were the first from the earth to reveal attempts to modify genes in human embryos using CRISPR. Three separate papers were published in scientific journals describing various studies in China on gene editing in human embryos.

When that will comes to the fresh research, “my reaction was, This particular will be an interesting incremental step, as well as also also boy, I bet that will’s going to get blown up as being more important than that will will be,” said Hank Greely, professor of law as well as also also genetics at Stanford University, who was not involved from the research.

Americans wary of gene-editing, brain chips, synthetic blood

“that will’s not the very first time anybody has CRISPR-ed human embryos. that will’s not the very first time anybody’s CRISPR-ed viable human embryos. that will’s certainly not the very first time people have CRISPR-ed viable mammalian embryos,” Greely said. “that will’s the very first time that will’s been done from the US, nevertheless the embryos don’t care where they are.”

Yet the research has already generated attention as well as also also controversy.

“This particular will be pushing the research faster than I thought we might see,” said Dana Carroll, professor of biochemistry at the University of Utah, if the MIT Technology Review report rings true. Carroll has used CRISPR in his own studies, nevertheless was not involved from the fresh research.

He pointed out that will the fresh research reportedly involved earlier, more delicate embryos, as well as also also CRISPR reportedly was still demonstrated as efficient.

“via the perspective of research that will might ultimately make germline editing safer as well as also also more effective, the earlier embryos will provide more relevant information,” he said.

CRISPR — an acronym for clustered, regularly interspaced, short palindromic repeats — allows scientists to cut as well as also also edit modest pieces of DNA at precise areas along a DNA strand, essentially modifying DNA.
Could the DNA-editing CRISPR revolutionize medicine?
Once scientists discovered that will they could develop a system that will modifies pieces of DNA, they tested the gene-editing technology in microbes, then non-human mammals, then non-human primates, as well as also also then, by 2015, human embryos.

The controversy surrounding gene-editing in human embryos partly stems via concern that will the modifications CRISPR makes in DNA can be passed down to the offspring of those embryos later in life, via generation to generation. Down the line, that will could possibly impact the genetic makeup of humans in erratic ways.

“There will be also considerable concern about off-target effects, such as doing mutations at sites from the genome additional than the intended target,” Carroll said. In additional words, an edit made in one area of DNA possibly could cause problems in another, as a ripple or domino effect, which could be concerning.

Some CRISPR critics also have argued that will gene-editing may give way to eugenics as well as also also to allowing embryos to be edited with certain features in order to develop so-called designer babies.

Though, not all experts are too concerned.

Treating diseases

“Some people are worried about, where’s This particular all going to head? Are we going to wind up with super babies as well as also also eugenics? as well as also also to me, I don’t find that will an interesting objection. that will’s too soon for that will objection,” Caplan said. “Clearly, if we’re going to let This particular research proceed, that will’s going to be to treat diseases as well as also also prevent diseases.”

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“I trust the applications will be for the treatment of serious diseases as well as also also in cases where a sensible alternative will be not available, as the National Academies’ report proposes,” Carroll said.

Greely said: “The National Academy of Sciences turned out using a big report on Valentine’s Day This particular year about genome editing in humans, as well as also also I thought they very usefully divided that will into three categories: basic research, treating living people, as well as also also doing modifications that will will pass down via generation to generation.”

As for the reported fresh research, “This particular will be category one. This particular will be basic research,” he said. “Category three will be the ethically crucial one; This particular isn’t that will. We’re still a long way via that will.”

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will be currently playing* @param containerId The parent container Id of the video element*/function findNextVideo(currentVideoId) {var i,vidObj;if (currentVideoId && jQuery.isArray(currentVideoCollection) && currentVideoCollection.length > 0) {for (i = 0; i 0) {videoEndSlateImpl.showEndSlateForContainer();}}}callbackObj = {onPlayerReady: function (containerId) {sy88pgw.VideoPlayer.reportLoadTime(containerId);sy88pgw.VideoPlayer.handleInitialExpandableVideoState(containerId);sy88pgw.VideoPlayer.handleAdOnCVPVisibilityChange(containerId, sy88pgw.pageVis.isDocumentVisible());if (Modernizr && !Modernizr.phone && !Modernizr.mobile && !Modernizr.tablet) {var containerClassId = ‘#’ + containerId;if (jQuery(containerClassId).parents(‘.js-pg-rail-tall__head’).length) {videoPinner = fresh sy88pgw.VideoPinner(containerClassId);videoPinner.init();} else {sy88pgw.VideoPlayer.hideThumbnail(containerId);}}},/** Listen to the metadata event which fires right after the ad ends as well as also also the actual video playback begins*/onContentEntryLoad: function(containerId, playerId, contentid, isQueue) {sy88pgw.VideoPlayer.showSpinner(containerId);},onContentMetadata: function (containerId, playerId, metadata, contentId, duration, width, height) {var endSlateLen = jQuery(document.getElementById(containerId)).parent().find(‘.js-video__end-slate’).eq(0).length;sy88pgw.VideoSourceUtils.updateSource(containerId, metadata);if (endSlateLen > 0) {videoEndSlateImpl.fetchAndShowRecommendedVideos(metadata);}},onAdPlay: function (containerId, cvpId, token, mode, id, duration, blockId, adType) {clearTimeout(moveToNextTimeout);if (blockId === 0) {(fresh Image()).src = “http://traffic.outbrain.com/network/trackpxl?advid=814&action=view”;}sy88pgw.VideoPlayer.hideSpinner(containerId);if (Modernizr && !Modernizr.phone && !Modernizr.mobile && !Modernizr.tablet) {if (typeof videoPinner !== ‘undefined’ && videoPinner !== null) {videoPinner.setIsPlaying(true);videoPinner.animateDown();}}},onContentPlay: function (containerId, cvpId, event) {var playerInstance,prevVideoId;/** When the video content starts playing, inject analytics data* for Aspen (if enabled) as well as also also the companion ad structure* (if that will was set when the ad played) should switch back to* epic ad structure. onContentPlay calls updateCompanionLayout* with the ‘restoreEpicAds’ structure to make This particular switch*/if (sy88pgw.companion && typeof sy88pgw.companion.updateCompanionLayout === ‘function’) {sy88pgw.companion.updateCompanionLayout(‘restoreEpicAds’);}clearTimeout(moveToNextTimeout);sy88pgw.VideoPlayer.hideSpinner(containerId);if (sy88pgw.VideoPlayer.getLibraryName(containerId) === ‘fave’) {playerInstance = FAVE.player.getInstance(containerId) || null;} else {playerInstance = containerId && window.cnnVideoManager.getPlayerByContainer(containerId).videoInstance.cvp || null;}prevVideoId = (window.jsmd && window.jsmd.v && (window.jsmd.v.eVar18 || window.jsmd.v.eVar4)) || ”;if (playerInstance && typeof playerInstance.reportAnalytics === ‘function’) {if (prevVideoId.length === 0 && document.referrer && document.referrer.search(//videos//) >= 0) {prevVideoId = document.referrer.replace(/^(?:http|https)://[^/]/videos/(.+.w+)(?:/video/playlists/.*)?$/, ‘/video/$1’);if (prevVideoId === document.referrer) {prevVideoId = ”;}}playerInstance.reportAnalytics(‘videoPageData’, {videoCollection: currentVideoCollectionId,videoBranding: sy88pgw.omniture.branding_content_page,templateType: sy88pgw.omniture.template_type,nextVideo: nextVideoId,previousVideo: prevVideoId,referrerType: ”,referrerUrl: document.referrer});}if (Modernizr && !Modernizr.phone && !Modernizr.mobile && !Modernizr.tablet) {if (typeof videoPinner !== ‘undefined’ && videoPinner !== null) {videoPinner.setIsPlaying(true);videoPinner.animateDown();}}},onContentReplayRequest: function (containerId, cvpId, contentId) {if (Modernizr && !Modernizr.phone && !Modernizr.mobile && !Modernizr.tablet) {if (typeof videoPinner !== ‘undefined’ && videoPinner !== null) {videoPinner.setIsPlaying(true);var $endSlate = jQuery(document.getElementById(containerId)).parent().find(‘.js-video__end-slate’).eq(0);if ($endSlate.length > 0) {$endSlate.removeClass(‘video__end-slate–active’).addClass(‘video__end-slate–inactive’);}}}},onContentBegin: function (containerId, cvpId, contentId) {sy88pgw.VideoPlayer.mutePlayer(containerId);if (sy88pgw.companion && typeof sy88pgw.companion.updateCompanionLayout === ‘function’) {sy88pgw.companion.updateCompanionLayout(‘removeEpicAds’);}sy88pgw.VideoPlayer.hideSpinner(containerId);clearTimeout(moveToNextTimeout);sy88pgw.VideoSourceUtils.clearSource(containerId);jQuery(document).triggerVideoContentStarted();},onContentComplete: function (containerId, cvpId, contentId) {if (sy88pgw.companion && typeof sy88pgw.companion.updateCompanionLayout === ‘function’) {sy88pgw.companion.updateCompanionLayout(‘restoreFreewheel’);}navigateToNextVideo(contentId, containerId);},onContentEnd: function (containerId, cvpId, contentId) {if (Modernizr && !Modernizr.phone && !Modernizr.mobile && !Modernizr.tablet) {if (typeof videoPinner !== ‘undefined’ && videoPinner !== null) {videoPinner.setIsPlaying(false);}}},onCVPVisibilityChange: function (containerId, cvpId, visible) {sy88pgw.VideoPlayer.handleAdOnCVPVisibilityChange(containerId, visible);}};if (typeof configObj.context !== ‘string’ || configObj.context.length 0) {configObj.adsection = window.ssid;}sy88pgw.autoPlayVideoExist = (sy88pgw.autoPlayVideoExist === true) ? true : false;sy88pgw.VideoPlayer.getLibrary(configObj, callbackObj, isLivePlayer);});/* videodemanddust will be a default feature of the injector */sy88pgw.INJECTOR.scriptComplete(‘videodemanddust’);

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